Article
Variant of TREM2 associated with the risk of Alzheimer's disease.
The New England journal of medicine - 10 Jan 2013
Jonsson Thorlakur, Stefansson Hreinn, Steinberg Stacy, Jonsdottir Ingileif, Jonsson Palmi V, Snaedal Jon, Bjornsson Sigurbjorn, Huttenlocher Johanna, Levey Allan I, Lah James J, Rujescu Dan, Hampel Harald, Giegling Ina, Andreassen Ole A, Engedal Knut, Ulstein Ingun, Djurovic Srdjan, Ibrahim-Verbaas Carla, Hofman Albert, Ikram M Arfan, van Duijn Cornelia M, Thorsteinsdottir Unnur, Kong Augustine, Stefansson Kari
Abstract excerpt
BACKGROUND: Sequence variants, including the ε4 allele of apolipoprotein E, have been associated with the risk of the common late-onset form of Alzheimer's disease. Few rare variants affecting the risk of late-onset Alzheimer's disease have been found. METHODS: We obtained the genome sequences of 2261 Icelanders and identified sequence variants that were likely to affect protein function. We imputed these...
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