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Article

TREM-1 SNP rs2234246 regulates TREM-1 protein and mRNA levels and is associated with plasma levels of L-selectin.

PloS one - 1 Jan 2017

Aldasoro Arguinano Alex-Ander, Dadé Sébastien, Stathopoulou Maria, Derive Marc, Coumba Ndiaye Ndeye, Xie Ting, Masson Christine, Gibot Sébastien, Visvikis-Siest Sophie

Abstract excerpt

High levels of TREM-1 are associated with cardiovascular and inflammatory diseases risks and the most recent studies have showed that TREM-1 deletion or blockade is associated with up to 60% reduction of the development of atherosclerosis. So far, it is unknown whether the levels of TREM-1 protein are genetically regulated. Moreover, TREM family receptors have been suggested to regulate the cellular adhesion...

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PMID: 28771614
DOI: 10.1371/journal.pone.0182226
PMCID: PMC5542552

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Source receipt: pubmed, retrieved 7 Sept 2026.

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