Article
TREM-1 SNP rs2234246 regulates TREM-1 protein and mRNA levels and is associated with plasma levels of L-selectin.
PloS one - 1 Jan 2017
Aldasoro Arguinano Alex-Ander, Dadé Sébastien, Stathopoulou Maria, Derive Marc, Coumba Ndiaye Ndeye, Xie Ting, Masson Christine, Gibot Sébastien, Visvikis-Siest Sophie
Abstract excerpt
High levels of TREM-1 are associated with cardiovascular and inflammatory diseases risks and the most recent studies have showed that TREM-1 deletion or blockade is associated with up to 60% reduction of the development of atherosclerosis. So far, it is unknown whether the levels of TREM-1 protei...
Topics
- Adult
- Alternative Splicing
- Atherosclerosis
- Binding Sites
- Female
- Gene Expression Regulation
- Gene Frequency
- Genotype
- Humans
- L-Selectin
- Leukocytes, Mononuclear
- Male