Article
Sox2 conditional mutation in mouse causes ataxic symptoms, cerebellar vermis hypoplasia, and postnatal defects of Bergmann glia.
Glia - 1 Sept 2018
Cerrato Valentina, Mercurio Sara, Leto Ketty, Fucà Elisa, Hoxha Eriola, Bottes Sara, Pagin Miriam, Milanese Marco, Ngan Chew-Yee, Concina Giulia, Ottolenghi Sergio, Wei Chia-Lin, Bonanno Giambattista, Pavesi Giulio, Tempia Filippo, Buffo Annalisa, Nicolis Silvia K
Abstract excerpt
Sox2 is a transcription factor active in the nervous system, within different cell types, ranging from radial glia neural stem cells to a few specific types of differentiated glia and neurons. Mutations in the human SOX2 transcription factor gene cause various central nervous system (CNS) abnormalities, involving hippocampus and eye defects, as well as ataxia. Conditional Sox2 mutation in mouse, with different...
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