Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ASTN2 in ASD and neurodevelopmental disorders.

Current topics in developmental biology - 1 Jan 2026

Govek Eve-Ellen, Hull Court, Hatten Mary E

Abstract excerpt

This chapter reviews the role of Astrotactin 2 (ASTN2) in cerebellar development and its implications for neurodevelopmental disorders, particularly autism spectrum disorder (ASD). ASTN2 is identified as a critical gene influencing the function of the cerebellum, a brain region traditionally associated with motor control but now recognized for its roles in social cognition and emotional processing. ASTN2...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autism Spectrum Disorder
Share to Cerebellum
Share to Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Nerve Tissue Proteins

Share to Neurodevelopmental Disorders

Source

Identifiers

PMID: 42025369
DOI: 10.1016/bs.ctdb.2026.02.003

Genes

ASTN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ASTN2 in ASD and neurodevelopmental disorders.PMID 42025369Read ↗

ASTN2 modulates synaptic strength by trafficking and degradation of surface proteinsSemantic proximity Read ↗

Bi-allelic variants in neuronal adhesion molecule astrotactin 1 gene ASTN1 cause diverse neurodevelopmental disorders.Semantic proximity Read ↗

Disruption of the ASTN2/TRIM32 locus at 9q33.1 is a risk factor in males for autism spectrum disorders, ADHD and other neurodevelopmental phenotypes.Semantic proximity Read ↗

ASD mutation of Katnal2 impairs ependymal ciliary motion and causes hydrocephalusSemantic proximity Read ↗

PTEN variant and genetic backgrounds combine to modify cerebellar neuronal differentiation in autism spectrum disorder.Semantic proximity Read ↗

GABA/Glutamate neuron differentiation imbalance and increased AKT/mTOR signalling in CNTNAP2 <sup>-/-</sup> cerebral organoidsSemantic proximity Read ↗

Species-conserved SYNGAP1 phenotypes associated with neurodevelopmental disorders.Semantic proximity Read ↗

Pathogenic variants in autism gene KATNAL2 cause hydrocephalus and disrupt neuronal connectivity by impairing ciliary microtubule dynamicsSemantic proximity Read ↗

Autism-associated <i>SCN2A</i> deficiency disrupts cortico-striatal circuitry in human brain assembloidsSemantic proximity Read ↗

Autism Spectrum Disorder: The Cerebellum, Genes, and PathwaysSemantic proximity Read ↗

Integrative Single-Cell Analysis of Autism Spectrum Disorder Animal Models Reveal Convergent Transcriptomic Dysregulation Involved in Excitatory-Inhibitory Imbalance and Glial DisfunctionSemantic proximity Read ↗

Behavioral and cerebellar transmission deficits in mice lacking the autism-linked gene islet brain-2.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.