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Article

Wnt5a is a crucial regulator of neurogenesis during cerebellum development.

Scientific reports - 16 Feb 2017

Subashini Chandramohan, Dhanesh Sivadasan Bindu, Chen Chih-Ming, Riya Paul Ann, Meera Vadakkath, Divya Thulasi Sheela, Kuruvilla Rejji, Buttler Kerstin, James Jackson

Abstract excerpt

The role of Wnt5a has been extensively explored in various aspects of development but its role in cerebellar development remains elusive. Here, for the first time we unravel the expression pattern and functional significance of Wnt5a in cerebellar development using Wnt5a-/- and Nestin-Cre mediated conditional knockout mouse models. We demonstrate that loss of Wnt5a results in cerebellar hypoplasia and depletion...

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Identifiers

PMID: 28205531
DOI: 10.1038/srep42523
PMCID: PMC5311982

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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