Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sox2 Requirement in Sonic Hedgehog-Associated Medulloblastoma

17 Apr 2013

Abstract excerpt

The transcription factor Sox2 has been shown to play essential roles during embryonic development as well as in cancer. To more precisely understand tumor biology and to identify potential therapeutical targets, we thoroughly investigated the expression and function of Sox2 in medulloblastoma, a malignant embryonic brain tumor that initiates in the posterior fossa and eventually spreads throughout the entire...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Glioma Diagnosis and Treatment
Share to Hedgehog Signaling Pathway Studies
Share to MicroRNA in disease regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23596255
DOI: 10.1158/0008-5472.can-13-0238

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sox2 Requirement in Sonic Hedgehog-Associated MedulloblastomaPMID 23596255Read ↗

Hippocampal development and neural stem cell maintenance require Sox2-dependent regulation of Shh.Semantic proximity Read ↗

Sox2 conditional mutation in mouse causes ataxic symptoms, cerebellar vermis hypoplasia, and postnatal defects of Bergmann glia.Semantic proximity Read ↗

Sox2: regulation of expression and contribution to brain tumorsSemantic proximity Read ↗

Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma.Semantic proximity Read ↗

Sox2-dependent maintenance of mouse oligodendroglioma involves the Sox2-mediated downregulation of Cdkn2b, Ebf1, Zfp423 and Hey2Semantic proximity Read ↗

Childhood Cerebellar Tumors Mirror Conserved Fetal Transcriptional ProgramsSemantic proximity Read ↗

Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells.Semantic proximity Read ↗

Elevating SOX2 Levels Deleteriously Affects the Growth of Medulloblastoma and Glioblastoma CellsSemantic proximity Read ↗

Cerebellar stem cells act as medulloblastoma-initiating cells in a mouse model and a neural stem cell signature characterizes a subset of human medulloblastomasSemantic proximity Read ↗

Sox2(+) stem/progenitor cells in the adult mouse pituitary support organ homeostasis and have tumor-inducing potential.Semantic proximity Read ↗

Sox2 deficiency causes neurodegeneration and impaired neurogenesis in the adult mouse brain.Semantic proximity Read ↗

OTX2 is critical for the maintenance and progression of Shh-independent medulloblastomas.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.