Article

An early Sox2-dependent gene expression program required for hippocampal dentate gyrus development

2020-08-16

Abstract excerpt

The hippocampus is a brain area central for cognition. Mutations in the human SOX2 transcription factor cause neurodevelopmental defects, leading to intellectual disability and seizures, together with hippocampal dysplasia. We generated an allelic series of Sox2 conditional mutations in mouse, deleting Sox2 at different developmental stages. Late Sox2 deletion (from E11.5, via Nestin-Cre) affects only postnatal hi...

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Literature Corpus work: 8ee4f705-b6cc-5319-bbe3-0c71709a4fbe
DOI: 10.1101/2020.08.16.252684

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