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Article

Sox2 deficiency causes neurodegeneration and impaired neurogenesis in the adult mouse brain.

Development (Cambridge, England) - 1 Aug 2004

Ferri Anna L M, Cavallaro Maurizio, Braida Daniela, Di Cristofano Antonello, Canta Annalisa, Vezzani Annamaria, Ottolenghi Sergio, Pandolfi Pier Paolo, Sala Mariaelvina, DeBiasi Silvia, Nicolis Silvia K

Abstract excerpt

In many species, the Sox2 transcription factor is a marker of the nervous system from the beginning of its development, and we have previously shown that Sox2 is expressed in embryonic neural stem cells. It is also expressed in, and is essential for, totipotent inner cell mass stem cells and other multipotent cell lineages, and its ablation causes early embryonic lethality. To investigate the role of Sox2 in the...

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PMID: 15240551
DOI: 10.1242/dev.01204

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Sox2 deficiency causes neurodegeneration and impaired neurogenesis in the adult mouse brain.PMID 15240551Read ↗

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