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Article

Interaction between a MAPT variant causing frontotemporal dementia and mutant APP affects axonal transport.

Neurobiology of aging - 1 Aug 2018

Adalbert Robert, Milde Stefan, Durrant Claire, Ando Kunie, Stygelbout Virginie, Yilmaz Zehra, Gould Stacey, Brion Jean-Pierre, Coleman Michael P

Abstract excerpt

In Alzheimer's disease, many indicators point to a central role for poor axonal transport, but the potential for stimulating axonal transport to alleviate the disease remains largely untested. Previously, we reported enhanced anterograde axonal transport of mitochondria in 8- to 11-month-old MAPTP301L knockin mice, a genetic model of frontotemporal dementia with parkinsonism-17T. In this study, we further...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29729423
DOI: 10.1016/j.neurobiolaging.2018.03.033
PMCID: PMC5998378

Genes

APP
MAPT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Interaction between a MAPT variant causing frontotemporal dementia and mutant APP affects axonal transport.PMID 29729423Read ↗

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The amyloid precursor protein and its derived fragments concomitantly contribute to the alterations of mitochondrial transport machinery in Alzheimer’s diseaseSemantic proximity Read ↗

Impaired retrograde transport by the Dynein/Dynactin complex contributes to Tau-induced toxicitySemantic proximity Read ↗

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