Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Parkinsonism and impaired axonal transport in a mouse model of frontotemporal dementia.

Proceedings of the National Academy of Sciences of the United States of America - 14 Oct 2008

Ittner Lars M, Fath Thomas, Ke Yazi D, Bi Mian, van Eersel Janet, Li Kong M, Gunning Peter, Götz Jürgen

Abstract excerpt

Frontotemporal dementia (FTD) is characterized by cognitive and behavioral changes and, in a significant subset of patients, Parkinsonism. Histopathologically, FTD frequently presents with tau-containing lesions, which in familial cases result from mutations in the MAPT gene encoding tau. Here we present a novel transgenic mouse strain (K3) that expresses human tau carrying the FTD mutation K369I. K3 mice develop...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Axonal Transport
Share to Dementia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Frontal Lobe

Share to Levodopa

Share to Parkinsonian Disorders

Share to Sciatic Nerve

Share to Substantia Nigra

Share to Temporal Lobe

Source

Open in PubMed Open full text

Identifiers

PMID: 18832465
DOI: 10.1073/pnas.0808084105
PMCID: PMC2572931

Genes

MAPT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Parkinsonism and impaired axonal transport in a mouse model of frontotemporal dementia.PMID 18832465Read ↗

Age-dependent axonal transport and locomotor changes and tau hypophosphorylation in a "P301L" tau knockin mouse.Semantic proximity Read ↗

Interaction between a MAPT variant causing frontotemporal dementia and mutant APP affects axonal transport.Semantic proximity Read ↗

Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein.Semantic proximity Read ↗

Cortical neuronal and glial pathology in TgTauP301L transgenic mice: neuronal degeneration, memory disturbance, and phenotypic variation.Semantic proximity Read ↗

Mouse models of frontotemporal dementia: A comparison of phenotypes with clinical symptomatology.Semantic proximity Read ↗

Lessons from Tau-Deficient MiceSemantic proximity Read ↗

Retarded axonal transport of R406W mutant tau in transgenic mice with a neurodegenerative tauopathy.Semantic proximity Read ↗

Different pathways of molecular pathophysiology underlie cognitive and motor tauopathy phenotypes in transgenic models for Alzheimer’s disease and frontotemporal lobar degenerationSemantic proximity Read ↗

Early-onset cognitive deficits and axonal transport dysfunction in P301S mutant tau transgenic mice.Semantic proximity Read ↗

Tau deposition drives neuropathological, inflammatory and behavioral abnormalities independently of neuronal loss in a novel mouse modelSemantic proximity Read ↗

Axonal transport defects: a common theme in neurodegenerative diseases.Semantic proximity Read ↗

Neurodegeneration with tau accumulation in a transgenic mouse expressing V337M human tau.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.