Article
Reduced number of axonal mitochondria and tau hypophosphorylation in mouse P301L tau knockin neurons.
Neurobiology of disease - 1 Jan 2016
Rodríguez-Martín Teresa, Pooler Amy M, Lau Dawn H W, Mórotz Gábor M, De Vos Kurt J, Gilley Jonathan, Coleman Michael P, Hanger Diane P
Abstract excerpt
Expression of the frontotemporal dementia-related tau mutation, P301L, at physiological levels in adult mouse brain (KI-P301L mice) results in overt hypophosphorylation of tau and age-dependent alterations in axonal mitochondrial transport in peripheral nerves. To determine the effects of P301L tau expression in the central nervous system, we examined the kinetics of mitochondrial axonal transport and tau...
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