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Article

Retarded axonal transport of R406W mutant tau in transgenic mice with a neurodegenerative tauopathy.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 12 May 2004

Zhang Bin, Higuchi Makoto, Yoshiyama Yasumasa, Ishihara Takeshi, Forman Mark S, Martinez Dan, Joyce Sonali, Trojanowski John Q, Lee Virginia M-Y

Abstract excerpt

Intracellular accumulations of filamentous tau inclusions are neuropathological hallmarks of neurodegenerative diseases known as tauopathies. The discovery of multiple pathogenic tau gene mutations in many kindreds with familial frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17) unequivocally confirmed the central role of tau abnormalities in the etiology of neurodegenerative disorders....

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Source

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Identifiers

PMID: 15140937
DOI: 10.1523/JNEUROSCI.0797-04.2004
PMCID: PMC6729383

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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