Article
Frontotemporal Lobar Dementia Mutant Tau Impairs Axonal Transport through a Protein Phosphatase 1γ-Dependent Mechanism.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 10 Nov 2021
Combs Benjamin, Christensen Kyle R, Richards Collin, Kneynsberg Andrew, Mueller Rebecca L, Morris Sarah L, Morfini Gerardo A, Brady Scott T, Kanaan Nicholas M
Abstract excerpt
Pathologic tau modifications are characteristic of Alzheimer's disease and related dementias, but mechanisms of tau toxicity continue to be debated. Inherited mutations in tau cause early onset frontotemporal lobar dementias (FTLD-tau) and are commonly used to model mechanisms of tau toxicity in tauopathies. Previous work in the isolated squid axoplasm model demonstrated that several pathogenic forms of tau...
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