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Article

Age-dependent axonal transport and locomotor changes and tau hypophosphorylation in a "P301L" tau knockin mouse.

Neurobiology of aging - 1 Mar 2012

Gilley Jonathan, Seereeram Anjan, Ando Kunie, Mosely Suzanne, Andrews Simon, Kerschensteiner Martin, Misgeld Thomas, Brion Jean-Pierre, Anderton Brian, Hanger Diane P, Coleman Michael P

Abstract excerpt

Tauopathies are characterized by hyperphosphorylation of the microtubule-associated protein tau and its accumulation into fibrillar aggregates. Toxic effects of aggregated tau and/or dysfunction of soluble tau could both contribute to neural defects in these neurodegenerative diseases. We have generated a novel knockin mouse model of an inherited tauopathy, frontotemporal dementia with parkinsonism linked to tau...

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Aging
Axonal Transport
Axons
Gene Knock-In Techniques
Hyperkinesis

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Primary Cell Culture

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PMID: 21492964
DOI: 10.1016/j.neurobiolaging.2011.02.014

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