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Article

Aberrant tau accumulation caused by MAPT mutations induces early pathological changes in axonal transport that are rescued by p38α inhibition.

Nature neuroscience - 1 Jun 2026

Moretto Edoardo, Masato Anna, Panzi Chiara, Lopes André T, Stuart Skye, De La-Rocque Samantha, Caso Maria Giuseppa, White Ian J, Harris Samuel S, Busche Marc Aurel, Schiavo Giampietro

Abstract excerpt

Impairments in axonal transport have been implicated in the pathogenesis of tauopathies, including frontotemporal dementia and Alzheimer's disease, yet the underlying mechanisms and reversibility of these deficits are largely unknown. In particular, the impacts of tau mutations, phosphorylation and aggregation on axonal transport in vivo remain controversial. By using two-photon imaging of axonal transport of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42243402
DOI: 10.1038/s41593-026-02266-4
PMCID: PMC13246509

Genes

BDNF
MAPT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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