Article

ALS mice carrying pathological mutant TDP-43, but not mutant FUS, display axonal transport defects <i>in vivo</i>

2018-10-09

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal, progressive neurodegenerative disease resulting from a complex interplay between genetics and environment. Impairments in the basic neuronal process of axonal transport have been identified in several ALS models. However, in vivo evidence of early/pre-symptomatic deficiencies in neuronal cargo trafficking remains limited, thus the pathogenic importance of axonal tra...

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Literature Corpus work: 6bfd0dc8-97f3-5665-889e-f58affb61a09
DOI: 10.1101/438812

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