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Article

Impaired retrograde transport by the Dynein/Dynactin complex contributes to Tau-induced toxicity

20 Mar 2015

Abstract excerpt

The gene mapt codes for the microtubule-associated protein Tau. The R406W amino acid substitution in Tau is associated with frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17) characterized by Tau-positive filamentous inclusions. These filamentous Tau inclusions are present in a group of neurodegenerative diseases known as tauopathies, including Alzheimer's disease (AD). To gain more...

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PMID: 25794683
DOI: 10.1093/hmg/ddv107

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