Article

Astrocyte calcium dysfunction causes early network hyperactivity in Alzheimer’s Disease

2022-04-26

Abstract excerpt

Dysfunctions of network activity and functional connectivity (FC) represent early events in Alzheimer’s disease (AD), but the underlying mechanisms remain unclear. Astrocytes regulate neuronal activity in the healthy brain, but their involvement in early network hyperactivity in AD is unknown. We show increased FC in the human cingulate cortex, several years before amyloid deposition. We found the same early cingu...

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Literature Corpus work: 3c2e3e70-9681-5490-aea3-eb438533e400
DOI: 10.1101/2022.04.26.489446

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