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Impaired neuromodulator crosstalk delays vigilance-dependent astroglia Ca <sup>2+</sup> activation in mouse models of Alzheimer’s disease

2022-06-30

Abstract excerpt

Degeneration in neuronal nuclei producing the neuromodulators acetylcholine and norepinephrine is a hallmark of Alzheimer’s disease (AD). Therapeutic interventions that increase acetylcholine in brain ameliorate AD symptoms in human patients, and augmenting norepinephrine restores cognitive function in mouse models of AD as well as Down Syndrome, the most frequent cause of early onset AD. A prominent cellular targ...

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Literature Corpus work
e0e398c6-dbef-58d2-8b3c-3631544a7338
DOI
10.1101/2022.06.27.497832
Open publication

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Impaired neuromodulator crosstalk delays vigilance-dependent astroglia Ca <sup>2+</sup> activation in mouse models of Alzheimer’s diseaseDOI 10.1101/2022.06.27.497832
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