Article
Meta-analysis of GWAS on both Chinese and European populations identifies GPR173 as a novel X chromosome susceptibility gene for SLE.
Arthritis research & therapy - 3 May 2018
Zhang Huoru, Zhang Yan, Wang Yong-Fei, Morris David, Hirankarn Nattiya, Sheng Yujun, Shen Jiangshan, Pan Hai-Feng, Yang Jing, Yang Sen, Cui Yong, Ye Dong-Qing, Vyse Timothy J, Zhang Xuejun, Lau Yu Lung, Yang Wanling
Abstract excerpt
BACKGROUND: Systemic lupus erythematous (SLE) is a complex autoimmune disease with female predominance, particularly affecting those of childbearing age. We performed analysis of three genome-wide genotyping datasets of populations of both Chinese and European origin. METHODS: This study involved 5695 cases and 10,357 controls in the discovery stage. The lead signal on chromosome X was followed by replication in...
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