Article
Meta-analysis of GWAS on two Chinese populations followed by replication identifies novel genetic variants on the X chromosome associated with systemic lupus erythematosus.
Human molecular genetics - 1 Jan 2015
Zhang Yan, Zhang Jing, Yang Jing, Wang Yongfei, Zhang Lu, Zuo Xianbo, Sun Liangdan, Pan Hai-Feng, Hirankarn Nattiya, Wang Tingyou, Chen Ruoyan, Ying Dingge, Zeng Shuai, Shen Jiangshan Jane, Lee Tsz Leung, Lau Chak Sing, Chan Tak Mao, Leung Alexander Moon Ho, Mok Chi Chiu, Wong Sik Nin, Lee Ka Wing, Ho Marco Hok Kung, Lee Pamela Pui Wah, Chung Brian Hon-Yin, Chong Chun Yin, Wong Raymond Woon Sing, Mok Mo Yin, Wong Wilfred Hing Sang, Tong Kwok Lung, Tse Niko Kei Chiu, Li Xiang-Pei, Avihingsanon Yingyos, Rianthavorn Pornpimol, Deekajorndej Thavatchai, Suphapeetiporn Kanya, Shotelersuk Vorasuk, Ying Shirley King Yee, Fung Samuel Ka Shun, Lai Wai Ming, Wong Chun-Ming, Ng Irene Oi Lin, Garcia-Barcelo Maria-Merce, Cherny Stacey S, Tam Paul Kwong-Hang, Sham Pak Chung, Yang Sen, Ye Dong Qing, Cui Yong, Zhang Xue-Jun, Lau Yu Lung, Yang Wanling
Abstract excerpt
Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease that affects mainly females. What role the X chromosome plays in the disease has always been an intriguing question. In this study, we examined the genetic variants on the X chromosome through meta-analysis of two genome-wide association studies (GWAS) on SLE on Chinese Han populations. Prominent association signals from the meta-analysis were...
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