Article
Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci.
Nature genetics - 1 Feb 2008
Harley John B, Alarcón-Riquelme Marta E, Criswell Lindsey A, Jacob Chaim O, Kimberly Robert P, Moser Kathy L, Tsao Betty P, Vyse Timothy J, Langefeld Carl D, Nath Swapan K, Guthridge Joel M, Cobb Beth L, Mirel Daniel B, Marion Miranda C, Williams Adrienne H, Divers Jasmin, Wang Wei, Frank Summer G, Namjou Bahram, Gabriel Stacey B, Lee Annette T, Gregersen Peter K, Behrens Timothy W, Taylor Kimberly E, Fernando Michelle, Zidovetzki Raphael, Gaffney Patrick M, Edberg Jeffrey C, Rioux John D, Ojwang Joshua O, James Judith A, Merrill Joan T, Gilkeson Gary S, Seldin Michael F, Yin Hong, Baechler Emily C, Li Quan-Zhen, Wakeland Edward K, Bruner Gail R, Kaufman Kenneth M, Kelly Jennifer A
Abstract excerpt
Systemic lupus erythematosus (SLE) is a common systemic autoimmune disease with complex etiology but strong clustering in families (lambda(S) = approximately 30). We performed a genome-wide association scan using 317,501 SNPs in 720 women of European ancestry with SLE and in 2,337 controls, and we genotyped consistently associated SNPs in two additional independent sample sets totaling 1,846 affected women and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.