Article
Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus.
Nature genetics - 1 Aug 2016
Morris David L, Sheng Yujun, Zhang Yan, Wang Yong-Fei, Zhu Zhengwei, Tombleson Philip, Chen Lingyan, Cunninghame Graham Deborah S, Bentham James, Roberts Amy L, Chen Ruoyan, Zuo Xianbo, Wang Tingyou, Wen Leilei, Yang Chao, Liu Lu, Yang Lulu, Li Feng, Huang Yuanbo, Yin Xianyong, Yang Sen, Rönnblom Lars, Fürnrohr Barbara G, Voll Reinhard E, Schett Georg, Costedoat-Chalumeau Nathalie, Gaffney Patrick M, Lau Yu Lung, Zhang Xuejun, Yang Wanling, Cui Yong, Vyse Timothy J
Abstract excerpt
Systemic lupus erythematosus (SLE; OMIM 152700) is a genetically complex autoimmune disease. Genome-wide association studies (GWASs) have identified more than 50 loci as robustly associated with the disease in single ancestries, but genome-wide transancestral studies have not been conducted. We combined three GWAS data sets from Chinese (1,659 cases and 3,398 controls) and European (4,036 cases and 6,959...
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