Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX.

doi:10.1056/NEJMoa0707865

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX.

The New England journal of medicine - 28 Feb 2008

Hom Geoffrey, Graham Robert R, Modrek Barmak, Taylor Kimberly E, Ortmann Ward, Garnier Sophie, Lee Annette T, Chung Sharon A, Ferreira Ricardo C, Pant P V Krishna, Ballinger Dennis G, Kosoy Roman, Demirci F Yesim, Kamboh M Ilyas, Kao Amy H, Tian Chao, Gunnarsson Iva, Bengtsson Anders A, Rantapää-Dahlqvist Solbritt, Petri Michelle, Manzi Susan, Seldin Michael F, Rönnblom Lars, Syvänen Ann-Christine, Criswell Lindsey A, Gregersen Peter K, Behrens Timothy W

Abstract excerpt

BACKGROUND: Systemic lupus erythematosus (SLE) is a clinically heterogeneous disease in which the risk of disease is influenced by complex genetic and environmental contributions. Alleles of HLA-DRB1, IRF5, and STAT4 are established susceptibility genes; there is strong evidence for the existence of additional risk loci. METHODS: We genotyped more than 500,000 single-nucleotide polymorphisms (SNPs) in DNA samples...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to B-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Case-Control Studies

Share to CD11b Antigen

Share to Genome, Human

Share to Lupus Erythematosus, Systemic

Share to North America

Share to src-Family Kinases

Share to Sweden

Source

Open in PubMed

Identifiers

PMID: 18204098
DOI: 10.1056/NEJMoa0707865

Genes

BLK
ITGAM
ITGAX
STAT4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX.PMID 18204098Read ↗

Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci.Semantic proximity Read ↗

Genetic susceptibility to systemic lupus erythematosus in the genomic era.Semantic proximity Read ↗

Association of the C8orf13-BLK region with systemic sclerosis in North-American and European populations.Semantic proximity Read ↗

Exome-wide association study identifies four novel loci for systemic lupus erythematosus in Han Chinese population.Semantic proximity Read ↗

A targeted association study in systemic lupus erythematosus identifies multiple susceptibility alleles.Semantic proximity Read ↗

Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.Semantic proximity Read ↗

Genetics research in systemic lupus erythematosus for clinicians: methodology, progress, and controversies.Semantic proximity Read ↗

Confirmation of five novel susceptibility loci for systemic lupus erythematosus (SLE) and integrated network analysis of 82 SLE susceptibility loci.Semantic proximity Read ↗

High-throughput identification of functional regulatory SNPs in systemic lupus erythematosusSemantic proximity Read ↗

Replication of GWAS-identified systemic lupus erythematosus susceptibility genes affirms B-cell receptor pathway signalling and strengthens the role of IRF5 in disease susceptibility in a Northern European population.Semantic proximity Read ↗

High-throughput identification of functional regulatory SNPs in systemic lupus erythematosus.Semantic proximity Read ↗

Multiple signals at the extended 8p23 locus are associated with susceptibility to systemic lupus erythematosus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.