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Article

From MGUS to Multiple Myeloma, a Paradigm for Clonal Evolution of Premalignant Cells.

Cancer research - 15 May 2018

van Nieuwenhuijzen Niels, Spaan Ingrid, Raymakers Reinier, Peperzak Victor

Abstract excerpt

Multiple myeloma (MM) is a treatable, but incurable, malignancy of plasma cells (PC) in the bone marrow (BM). It represents the final stage in a continuum of PC dyscrasias and is consistently preceded by a premalignant phase termed monoclonal gammopathy of undetermined significance (MGUS). The existence of this well-defined premalignant phase provides the opportunity to study clonal evolution of a premalignant...

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Identifiers

PMID: 29703720
DOI: 10.1158/0008-5472.CAN-17-3115

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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