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Article

Subclonal evolution in disease progression from MGUS/SMM to multiple myeloma is characterised by clonal stability

25 Jul 2018

Abstract excerpt

Multiple myeloma (MM) is a largely incurable haematological malignancy defined by the clonal proliferation of malignant plasma cells (PCs) within the bone marrow. Clonal heterogeneity has recently been established as a feature in MM, however, the subclonal evolution associated with disease progression has not been described. Here, we performed whole-exome sequencing of serial samples from 10 patients, providing...

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PMID: 30046162
DOI: 10.1038/s41375-018-0206-x

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