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Article

Serial exome analysis of disease progression in premalignant gammopathies

5 Feb 2014

Abstract excerpt

Nearly all human cancers are preceded by precursor states far more prevalent than clinical malignancy itself. Understanding which premalignant lesions are truly biologically premalignant versus those with impending clinical progression (biologically malignant) is a central question in cancer biology. Tracking the progression of human premalignant states (or lack thereof) in vivo is not feasible in most tumors...

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PMID: 24496302
DOI: 10.1038/leu.2014.59

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