Article
A Comprehensive Review of the Genomics of Multiple Myeloma: Evolutionary Trajectories, Gene Expression Profiling, and Emerging Therapeutics.
Cells - 2 Aug 2021
Awada Hassan, Thapa Bicky, Awada Hussein, Dong Jing, Gurnari Carmelo, Hari Parameswaran, Dhakal Binod
Abstract excerpt
Multiple myeloma (MM) is a blood cancer characterized by the accumulation of malignant monoclonal plasma cells in the bone marrow. It develops through a series of premalignant plasma cell dyscrasia stages, most notable of which is the Monoclonal Gammopathy of Undetermined Significance (MGUS). Significant advances have been achieved in uncovering the genomic aberrancies underlying the pathogenesis of MGUS-MM. In...
Topics
- Ataxia Telangiectasia Mutated Proteins
- Gene Expression
- Humans
- Monoclonal Gammopathy of Undetermined Significance
- Multiple Myeloma
- Poly(ADP-ribose) Polymerase Inhibitors
- Polymorphism, Single Nucleotide
- Prognosis
- Tumor Suppressor Protein p53