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Genomics Define Malignant Transformation in Myeloma Precursor Conditions

8 Oct 2025

Abstract excerpt

Multiple myeloma (MM) is consistently preceded by monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM). While these precursor conditions are asymptomatic, they are not entirely benign and carry a lifelong risk of progression to MM. Unlike other cancers defined by pathology, malignant transformation from MGUS or SMM to MM has so far relied on demonstration of clinical...

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PMID: 41061199
DOI: 10.1200/jco-25-01733

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