Article
Novel insight into mutational landscape of head and neck squamous cell carcinoma.
PloS one - 1 Jan 2014
Gaykalova Daria A, Mambo Elizabeth, Choudhary Ashish, Houghton Jeffery, Buddavarapu Kalyan, Sanford Tiffany, Darden Will, Adai Alex, Hadd Andrew, Latham Gary, Danilova Ludmila V, Bishop Justin, Li Ryan J, Westra William H, Hennessey Patrick, Koch Wayne M, Ochs Michael F, Califano Joseph A, Sun Wenyue
Abstract excerpt
Development of head and neck squamous cell carcinoma (HNSCC) is characterized by accumulation of mutations in several oncogenes and tumor suppressor genes. We have formerly described the mutation pattern of HNSCC and described NOTCH signaling pathway alterations. Given the complexity of the HNSCC, here we extend the previous study to understand the overall HNSCC mutation context and to discover additional genetic...
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