Oncogenic driver mutations predict outcome in a cohort of head and neck squamous cell carcinoma (HNSCC) patients within a clinical trial.

doi:10.1038/s41598-020-72927-2

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Article

Oncogenic driver mutations predict outcome in a cohort of head and neck squamous cell carcinoma (HNSCC) patients within a clinical trial.

Scientific reports - 6 Oct 2020

Fernández-Mateos Javier, Pérez-García Jéssica, Seijas-Tamayo Raquel, Mesía Ricard, Rubió-Casadevall Jordi, García-Girón Carlos, Iglesias Lara, Carral Maseda Alberto, Adansa Klain Juan Carlos, Taberna Miren, Vazquez Silvia, Gómez María Asunción, Del Barco Edel, Ocana Alberto, González-Sarmiento Rogelio, Cruz-Hernández Juan Jesús

Abstract excerpt

234 diagnostic formalin-fixed paraffin-embedded (FFPE) blocks from homogeneously treated patients with locally advanced head and neck squamous cell carcinoma (HNSCC) within a multicentre phase III clinical trial were characterised. The mutational spectrum was examined by next generation sequencing in the 26 most frequent oncogenic drivers in cancer and correlated with treatment response and survival. Human...

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PMID: 33024167
DOI: 10.1038/s41598-020-72927-2
PMCID: PMC7539152

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TP53

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