Establishing a genetic mutation panel for predicting malignant transformation of oral leukoplakia: A prospective cohort study.

doi:10.1016/j.oraloncology.2026.108110

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Establishing a genetic mutation panel for predicting malignant transformation of oral leukoplakia: A prospective cohort study.

Oral oncology - 1 Oct 2026

Zhu Yuhan, Wang Zirui, Li Chenxi, Shi Linjun, Liu Wei

Abstract excerpt

OBJECTIVE: To investigate somatic mutations in the whole genes of tissue samples from patients with oral leukoplakia (OLK), as the most typical precursor of oral cancer; and identify the specific genes as a mutational panel for predicting OLK malignant transformation. METHODS: A total of 123 consecutive OLK patients with long-term follow-up (median, 73 months) were prospectively enrolled, and divided into...

Read the complete abstract on PubMed

Topics

Humans
Leukoplakia, Oral
Female
Male
Prospective Studies
Mutation
Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Middle Aged

Aged

Caspase 8

Mouth Neoplasms

Tumor Suppressor Protein p53

Adult

Prognosis

Source

Open in PubMed

Identifiers

PMID: 42574788
DOI: 10.1016/j.oraloncology.2026.108110

Genes

CASP8
CYP2B6
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Establishing a genetic mutation panel for predicting malignant transformation of oral leukoplakia: A prospective cohort study.PMID 42574788Read ↗

Oral cancer driver gene mutations in oral potentially malignant disorders: clinical significance and diagnostic implicationsSemantic proximity Read ↗

Identification of Biomarkers Associated with Cancerous Change in Oral Leukoplakia Based on Integrated Transcriptome AnalysisSemantic proximity Read ↗

The genetic basis of oral leukoplakia and its key role in understanding oral carcinogenesis.Semantic proximity Read ↗

Integrative analysis of genomic and transcriptomic data of normal, tumour, and co-occurring leukoplakia tissue triads drawn from patients with gingivobuccal oral cancer identifies signatures of tumour initiation and progression.Semantic proximity Read ↗

Identification of Potential Oral Cancer-Specific Biomarker in Oral Potentially Malignant Disorders for Early Detection of Malignancy: A Systematic ReviewSemantic proximity Read ↗

Molecular, genomic and mutational landscape of oral leukoplakiaSemantic proximity Read ↗

Oral Potentially Malignant Disorders: Etiology, Pathogenesis, and Transformation Into Oral CancerSemantic proximity Read ↗

Copy Number Alterations Predict Development of OSCC from Oral LeukoplakiaSemantic proximity Read ↗

Integrated analysis of oral tongue squamous cell carcinoma identifies key variants and pathways linked to risk habits, HPV, clinical parameters and tumor recurrenceSemantic proximity Read ↗

Study of Caspase 8 mutation in oral cancer and adjacent precancer tissues and implication in progression.Semantic proximity Read ↗

Integrated analysis of oral tongue squamous cell carcinoma identifies key variants and pathways linked to risk habits, HPV, clinical parameters and tumor recurrenceSemantic proximity Read ↗

Development and Validation of an Immune-related Gene Diagnostic Model for Cancerous Change in Oral LeukoplakiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.