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Article

3p21, 5q21, 9p21 and 17p13 allelic deletions accumulate in the dysplastic spectrum of laryngeal carcinogenesis and precede malignant transformation.

Histology and histopathology - 1 Oct 2003

Sanz-Ortega J, Valor C, Saez M C, Ortega L, Sierra E, Poch J, Hernández S, Sanz-Esponera J

Abstract excerpt

A tissue field of somatic genetic alterations precede the histopathological phenotypic changes of carcinoma. Loss of Heterozygosity (LOH) at the sites of known or putative tumor suppressor genes is a common genetic abnormality detected in precancerous conditions. These genomic changes could be of potential use in the diagnosis and prognosis of pre-malignant laryngeal lesions. Recently the concept of laryngeal...

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Identifiers

PMID: 12973674
DOI: 10.14670/HH-18.1053

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APC

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Source receipt: pubmed, retrieved 7 Sept 2026.

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