Article
Genomic imbalances in precancerous tissues signal oral cancer risk.
Molecular cancer - 23 Jul 2009
Garnis Cathie, Chari Raj, Buys Timon P H, Zhang Lewei, Ng Raymond T, Rosin Miriam P, Lam Wan L
Abstract excerpt
Oral cancer develops through a series of histopathological stages: through mild (low grade), moderate, and severe (high grade) dysplasia to carcinoma in situ and then invasive disease. Early detection of those oral premalignant lesions (OPLs) that will develop into invasive tumors is necessary to improve the poor prognosis of oral cancer. Because no tools exist for delineating progression risk in low grade oral...
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