Article
The mutational landscape of early- and typical-onset oral tongue squamous cell carcinoma.
Cancer - 15 Feb 2021
Campbell Benjamin R, Chen Zhishan, Faden Daniel L, Agrawal Nishant, Li Ryan J, Hanna Glenn J, Iyer N Gopalakrishna, Boot Arnoud, Rozen Steven G, Vettore Andre L, Panda Binay, Krishnan Neeraja M, Pickering Curtis R, Myers Jeffrey N, Guo Xingyi, Lang Kuhs Krystle A
Abstract excerpt
BACKGROUND: The incidence of oral tongue squamous cell carcinoma (OTSCC) is increasing among younger birth cohorts. The etiology of early-onset OTSCC (diagnosed before the age of 50 years) and cancer driver genes remain largely unknown. METHODS: The Sequencing Consortium of Oral Tongue Cancer was established through the pooling of somatic mutation data of oral tongue cancer specimens (n = 227 [107 early-onset...
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