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Article

Extremely early genomic events and temporal order of esophageal squamous cell carcinogenesis: Longitudinal self-comparison of progressors and non-progressors.

American journal of human genetics - 7 Aug 2025

Liu Ying, Liu Mengfei, Yang Yang, Cao Lihua, He Wei, Liu Zhen, Guo Chuanhai, Pan Yaqi, Liu Fangfang, Hu Zhe, Chen Huanyu, Cai Hong, He Zhonghu, Wu Jianmin, Ke Yang

Abstract excerpt

The current surveillance guideline of esophageal squamous cell carcinoma (ESCC) runs the risk of underestimation of early Lugol-unstained lesions (LULs), and extremely early genomic events in the carcinogenesis and their temporal order of occurrence remain unclear. Here, we performed whole-exome sequencing analyses of 148 biopsy samples obtained at different time points (with a median 4.6-year interval) from the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40628272
DOI: 10.1016/j.ajhg.2025.06.008
PMCID: PMC12414684

Genes

CDKN2A
NOTCH1
TP53
CCND1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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