Article

Analysis of Mutational Profile of Hypopharyngeal and Laryngeal Head and Neck Cancers Identifies <i>KMT2C</i> as a Potential Tumor Suppressor

2021-08-30

Abstract excerpt

Hypopharyngeal cancer represents one of worst types of head and neck tumors with only few studies focusing on the genomic profile of this type of cancer. Using targeted next-generation sequencing we analyzed 48 HPV-negative tumor samples including 23 originating from hypopharynx, and 25 from larynx. Among genes previously described as significantly mutated, TP53, FAT1, NOTCH1, KMT2C and CDKN2A were found to be mos...

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Literature Corpus work: 2269e915-c25c-5795-a7fb-548aa802ed73
DOI: 10.1101/2021.08.24.21262521

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