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Identification of ALPPL2 as a Naive Pluripotent State-Specific Surface Protein Essential for Human Naive Pluripotency Regulation.

Cell reports - 17 Mar 2020

Bi Yan, Tu Zhifen, Zhang Yanping, Yang Peng, Guo Mingyue, Zhu Xuehao, Zhao Chengchen, Zhou Jianfeng, Wang Hong, Wang Yixuan, Gao Shaorong

Abstract excerpt

Human naive pluripotent stem cells established from the epiblasts of preimplantation blastocysts provide a useful model for mechanistic studies of pluripotency regulation and lineage differentiation. Important advances have been made to optimize culture conditions and define molecular criteria for naive pluripotency. However, the identity of naive-specific surface markers and the underlying molecular mechanism of...

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PMID: 32187559
DOI: 10.1016/j.celrep.2020.02.090

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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