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Cell fate roadmap of human primed-to-naive transition reveals preimplantation cell lineage signatures

7 Jun 2022

Abstract excerpt

Human naive pluripotent stem cells offer a unique window into early embryogenesis studies. Recent studies have reported several strategies to obtain cells in the naive state. However, cell fate transitions and the underlying mechanisms remain poorly understood. Here, by a dual fluorescent reporter system, we depict the cell fate dynamics from primed state toward naive pluripotency with ALPG activation followed by...

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PMID: 35672317
DOI: 10.1038/s41467-022-30924-1

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