Article
Chromatin priming by transcription factor ELF3 confers transcriptional competence for amniotic differentiation on primed human embryonic stem cells
2025-08-05
Abstract excerpt
The self-organizing emergence of the amniotic lineage in synthetic human embryo models suggests that embryonic pluripotent cells possess an intrinsic potential to initiate extraembryonic amniotic differentiation. However, it remains poorly understood how this intrinsic amniotic competence is established and how it is linked to pluripotency. In this study, we found that the transcription factor ELF3, whose expressi...
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Identifiers and source
- Literature Corpus work
- 9d87408a-32e5-5852-be06-b918aff2344c
- DOI
- 10.1101/2025.08.04.668400