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Article

Activation of β-catenin signaling in aggrecan-expressing cells in temporomandibular joint causes osteoarthritis-like defects.

International journal of oral science - 23 Apr 2018

Hui Tianqian, Zhou Yachuan, Wang Tingyu, Li Jun, Zhang Shanxing, Liao Lifan, Gu Jianhong, Ye Ling, Zhao Lan, Chen Di

Abstract excerpt

β-Catenin plays a critical role in cartilage formation and development. To further understand the role of β-catenin in osteoarthritis (OA) development in temporomandibular joint (TMJ), we have generated β-catenin conditional activation mice (β-cat(ex3) Agc1CreER ) by breeding Agc1-CreER mice with β-cateninflox(ex3)/+ mice. Results of histologic analysis showed the progressive TMJ defects in 3- and 6-month-old...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29686224
DOI: 10.1038/s41368-018-0016-z
PMCID: PMC5966811

Genes

MMP13
PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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