Article
Roles of β-catenin signaling in phenotypic expression and proliferation of articular cartilage superficial zone cells.
Laboratory investigation; a journal of technical methods and pathology - 1 Dec 2011
Yasuhara Rika, Ohta Yoichi, Yuasa Takahito, Kondo Naoki, Hoang Tai, Addya Sankar, Fortina Paolo, Pacifici Maurizio, Iwamoto Masahiro, Enomoto-Iwamoto Motomi
Abstract excerpt
The superficial zone (SFZ) of articular cartilage has unique structural and biomechanical features, is thought to promote self-renewal of articular cartilage, and is thus important for joint long-term function, but the mechanisms regulating its properties remain unclear. Previous studies revealed that Wnt/β-catenin signaling is continuously active in SFZ, indicating that it may be essential for SFZ function....
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