Article
Activation of beta-catenin signaling in articular chondrocytes leads to osteoarthritis-like phenotype in adult beta-catenin conditional activation mice.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jan 2009
Zhu Mei, Tang Dezhi, Wu Qiuqian, Hao Suyang, Chen Mo, Xie Chao, Rosier Randy N, O'Keefe Regis J, Zuscik Michael, Chen Di
Abstract excerpt
Osteoarthritis (OA) is a degenerative joint disease, and the mechanism of its pathogenesis is poorly understood. Recent human genetic association studies showed that mutations in the Frzb gene predispose patients to OA, suggesting that the Wnt/beta-catenin signaling may be the key pathway to the development of OA. However, direct genetic evidence for beta-catenin in this disease has not been reported. Because...
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