Article
Regulation of the chondrocyte phenotype by beta-catenin.
Development (Cambridge, England) - 1 Dec 2002
Ryu Je-Hwang, Kim Song-Ja, Kim Seon-Hee, Oh Chun-Do, Hwang Sang-Gu, Chun Churl-Hong, Oh Seung-Hyun, Seong Je-Kyung, Huh Tae-Lin, Chun Jang-Soo
Abstract excerpt
beta-Catenin regulates important biological processes, including embryonic development and tumorigenesis. We have investigated the role of beta-catenin in the regulation of the chondrocyte phenotype. Expression of beta-catenin was high in prechondrogenic mesenchymal cells, but significantly decreased in differentiated chondrocytes both in vivo and in vitro. Accumulation of beta-catenin by the inhibition of...
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