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Article

Conditional activation of β‐catenin signaling in mice leads to severe defects in intervertebral disc tissue

15 Mar 2012

Abstract excerpt

OBJECTIVE: The incidence of low back pain is extremely high and is often linked to intervertebral disc (IVD) degeneration. The mechanism of this disease is currently unknown. This study was undertaken to investigate the role of β-catenin signaling in IVD tissue function. METHODS: β-catenin protein levels were measured by immunohistochemical analysis of disc samples obtained from patients with disc degeneration...

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Share to Cervical and Thoracic Myelopathy
Share to Spine and Intervertebral Disc Pathology
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PMID: 22422036
DOI: 10.1002/art.34469

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