Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cbfβ regulates Wnt/β-catenin, Hippo/Yap, and Tgfβ signaling pathways in articular cartilage homeostasis and protects from ACLT surgery-induced osteoarthritis

1 May 2024

Abstract excerpt

As the most common degenerative joint disease, osteoarthritis (OA) contributes significantly to pain and disability during aging. Several genes of interest involved in articular cartilage damage in OA have been identified. However, the direct causes of OA are poorly understood. Evaluating the public human RNA-seq dataset showed that CBFB (subunit of a heterodimeric Cbfβ/Runx1, Runx2, or Runx3 complex) expression...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related gene regulation
Share to Hippo pathway signaling and YAP/TAZ
Share to Osteoarthritis Treatment and Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38805545
DOI: 10.7554/elife.95640

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cbfβ regulates Wnt/β-catenin, Hippo/Yap, and Tgfβ signaling pathways in articular cartilage homeostasis and protects from ACLT surgery-induced osteoarthritisPMID 38805545Read ↗

Cbfβ regulates Wnt/β-catenin, Hippo/Yap, and TGFβ signaling pathways in articular cartilage homeostasis and protects from ACLT surgery-induced osteoarthritisSemantic proximity Read ↗

Deficiency of Cbfβ in articular cartilage leads to osteoarthritis-like phenotype through Hippo/Yap, TGFβ, and Wnt/β-catenin signaling pathways.Semantic proximity Read ↗

Runx1 protects against the pathological progression of osteoarthritisSemantic proximity Read ↗

Activation of beta-catenin signaling in articular chondrocytes leads to osteoarthritis-like phenotype in adult beta-catenin conditional activation mice.Semantic proximity Read ↗

Cbfβ: A key regulator in skeletal stem cell differentiation, bone development, and diseaseSemantic proximity Read ↗

Age-associated spontaneous activation of BMP signaling inhibits the canonical Wnt pathway through ICAT to promote osteoarthritisSemantic proximity Read ↗

Insights on Biology and Pathology of HIF-1α/-2α, TGFβ/BMP, Wnt/β-Catenin, and NF-κB Pathways in OsteoarthritisSemantic proximity Read ↗

IGF1 drives Wnt-induced joint damage and is a potential therapeutic target for osteoarthritisSemantic proximity Read ↗

Bulk RNA ‐seq analyses of mandibular condylar cartilage in a post‐traumatic TMJ osteoarthritis rabbit modelSemantic proximity Read ↗

Unique TMJ-specific transcriptomic signature and its medial layer: Implications in osteoarthritisSemantic proximity Read ↗

Wnt/PCP-YAP-BIRC2 axis maintains cartilage stem/progenitor cell homeostasis in osteoarthritisSemantic proximity Read ↗

TCF12 regulates the TGF-β/Smad2/3 signaling pathway to accelerate the progression of osteoarthritis by targeting CXCR4Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.