Activation of β‐catenin in Col2 ‐expressing chondrocytes leads to osteoarthritis‐like defects in hip joint

Abstract excerpt

Abstract Although osteoarthritis (OA) in the hip joint is a common and debilitating degenerative disease, the precise molecular mechanisms underlying its pathological process remains unclear. This study sets out to investigate whether β‐catenin plays a critical role in hip OA pathogenesis. Here, we showed overexpressed β‐catenin protein in human OA cartilage tissues. Then, we analyzed β‐cat(ex3) Col2ER mice, in...

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