Article
Activation of β-catenin in Col2-expressing chondrocytes leads to osteoarthritis-like defects in hip joint.
Journal of cellular physiology - 1 Aug 2019
Xia Chenjie, Wang Pinger, Fang Liang, Ge Qinwen, Zou Zhen, Dong Rui, Zhang Peng, Shi Zhenyu, Xu Rui, Zhang Lei, Luo Chen, Ying Jun, Xiao Luwei, Shen Jie, Chen Di, Tong Peijian, Jin Hongting
Abstract excerpt
Although osteoarthritis (OA) in the hip joint is a common and debilitating degenerative disease, the precise molecular mechanisms underlying its pathological process remains unclear. This study sets out to investigate whether β-catenin plays a critical role in hip OA pathogenesis. Here, we showed overexpressed β-catenin protein in human OA cartilage tissues. Then, we analyzed β-cat(ex3)Col2ER mice, in which...
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