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Article

Deficiency of Cbfβ in articular cartilage leads to osteoarthritis-like phenotype through Hippo/Yap, TGFβ, and Wnt/β-catenin signaling pathways.

International journal of biological sciences - 1 Jan 2024

Zhang Yan, Chen Huiwen, Wu Jinjin, McVicar Abigail, Chen Yilin, Su Jiacan, Li Yi-Ping, Chen Wei

Abstract excerpt

Osteoarthritis (OA) is the most prevalent degenerative joint disorder, causing physical impairments among the elderly. Core binding factor subunit β (Cbfβ) has a critical role in bone homeostasis and cartilage development. However, the function and mechanism of Cbfβ in articular cartilage and OA remains unclear. We found that Cbfβf/fAggrecan-CreERT mice with Cbfβ-deficiency in articular cartilage developed a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38617544
DOI: 10.7150/ijbs.90250
PMCID: PMC11008268

Genes

TCF4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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