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Article

Ubiquitin COOH-terminal hydrolase L1 deletion is associated with urinary α-klotho deficiency and perturbed phosphate homeostasis.

American journal of physiology. Renal physiology - 1 Aug 2018

Boisvert Naomi C, Holterman Chet E, Gutsol Alexey, Coulombe Josée, Pan Wanling, Alexander R Todd, Gray Douglas A, Kennedy Chris R

Abstract excerpt

Loss of ubiquitin COOH-terminal hydrolase L1 (UCHL1), a deubiquitinating enzyme required for neuronal function, led to hyperphosphatemia accompanied by phosphaturia in mice, while calcium homeostasis remained intact. We therefore investigated the mechanisms underlying the phosphate imbalance in Uchl1-/- mice. Interestingly, phosphaturia was not a result of lower renal brush border membrane sodium-phosphate...

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Source

Identifiers

PMID: 29667913
DOI: 10.1152/ajprenal.00411.2017

Genes

UCHL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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