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Article

In vivo evidence for an interplay of FGF23/Klotho/PTH axis on the phosphate handling in renal proximal tubules.

American journal of physiology. Renal physiology - 1 Nov 2018

Ide Noriko, Ye Rui, Courbebaisse Marie, Olauson Hannes, Densmore Michael J, Larsson Tobias E, Hanai Jun-Ichi, Lanske Beate

Abstract excerpt

Phosphate homeostasis is primarily maintained in the renal proximal tubules, where the expression of sodium/phosphate cotransporters (Npt2a and Npt2c) is modified by the endocrine actions of both fibroblast growth factor 23 (FGF23) and parathyroid hormone (PTH). However, the specific contribution of each regulatory pathway in the proximal tubules has not been fully elucidated in vivo. We have previously...

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Source

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Identifiers

PMID: 29993278
DOI: 10.1152/ajprenal.00650.2017
PMCID: PMC6293295

Genes

FGF23
PTH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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In vivo evidence for an interplay of FGF23/Klotho/PTH axis on the phosphate handling in renal proximal tubules.PMID 29993278Read ↗

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